References of Fucoxanthin

October 5th, 2014

As a R&D driven company, Beijing Gingko Group (BGG) emphasizes scientific research and develops novel products supported by scientific data. By collaborating with Zhajiang University, a prestigious food health research institute in China, we have found that BGG’s ThinOgen™ fucoxanthin regulates the body weight of high fat diet induced obese rats effectively by improving lipid metabolism, and reducing the levels of serum total cholesterol, triglycerides, and leptin.

Ref. 0110

Title: Combination of fucoxanthin and conjugated linoleic acid attenuates bodyweight gain and improves lipid metabolism in high-fat diet-induced obese rats

Authors: Xiaojie Hu, Yanmei Li,Chunhua Li, Yuanqing Fu, Fang Cai, Qi Chen, Duo Li

Magazine:Archives of Biochemistry and Biophysics, 2012, 519: 59–65.


The present study investigated the effects of combined fucoxanthin (Fc) and conjugated linoleic acid(CLA) on high-fat diet-induced obese rats. Thirty five rats were divided into four groups, fed a high-fatdiet (Control, 15% fat, wt/wt), supplemented with low Fc (FCL, 0.083 mg/kg/bw), high Fc (FCH,0.167 mg/kg/bw) and FCL (0.083 mg/kg/bw) plus CLA (0.15 g/kg/bw) (FCL + CLA) for 52d. Body weightand white adipose tissue (WAT) weight were significantly suppressed in FCL + CLA group than those incontrol group. WAT weight was also markedly attenuated in FCL and FCH groups. Accumulation of hepatic lipid droplets and the perirenal adipocyte size of FCL, FCH and FCL + CLA groups were diminished compared to control group. Serum total cholesterol level in FCH group, triacylglycerol and leptin levels in FCL,FCH and FCL + CLA groups, and glucose concentration in FCH and FCL + CLA groups were significantlydecreased than those in control group. The mRNA expression of adiponectin, adipose triacylglycerollipase, carnitinepalmitoyltransferase 1A was remarkably up-regulated in FCL, FCH and FCL + CLA groups.These results suggest that Fc and FCL + CLA could reduce serum levels of triacylglycerol, glucose and leptin, and FCL + CLA could exert anti-obesity effects by regulating mRNA expression of enzymes related tolipid metabolism in WAT of diet-induced obesity rats.


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