Origin:
Haematococcus pluvialisis

Standards:

2%, 4% water-dispersible powder
5%, 10%, 20% oleoresin
2.5% beadlets

Health Benefits:
Anti-Fatigue | Anti-Oxidant | Health Support for Skin, Eye, Brain, Liver, Heart

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Astaxanthin

WORLD’S STRONGEST & HIGHEST QUALITY NATURAL ANTIOXIDANT

 Clinical Trial Results

• Reduces various oxidative stress markers
• Prevents oxidative damage
• Prevents peroxidation of blood lipids including LDL cholesterol
• Prevents depletion of non-enzymatic antioxidant defense

Dosage range: 2mg to 4mg per day

In-Vitro Research Results

• Multiple times stronger than all other antioxidants tested in various head-to-head antioxidant experiments regardless of testing method
• Generally at least 10X stronger than all other carotenoids
• 800X stronger than CoQ10
• 550X stronger than Vitamin E
• 6000X stronger than Vitamin C
• 20X to 90X stronger than Synthetic Astaxanthin as an antioxidant in three separate tests from two peer-reviewed studies¹

JOINT, TENDON & MUSCLE SUPPORT

Clinical Trial Results

• Supports Joint Health in Rheumatoid Arthritis: May help alleviate joint pain and improve overall comfort.
• Aids Carpal Tunnel Syndrome Relief: Contributes to reduced pain intensity and duration.
• Supports Tendon Health and Mobility: Demonstrated to improve grip strength by up to 93% in individuals with tendonitis (e.g., tennis elbow), with decreased pain and improved mobility.
• Enhances Comfort in Active Lifestyles: Helps reduce joint and muscle discomfort in individuals undergoing heavy physical training.

In-Vitro Research Results

Astaxanthin has been shown to support 8 different inflammatory response markers without side effects or contraindications

EYE HEALTH

Clinical Trial Results

• Dose-dependently improves visual acuity (the ability to see fine detail)
• Improves depth perception
• Improves eye fatigue
• Also can prevent eye fatigue
• Increases retinal capillary blood flow
• Increases blood flow velocity to the eyes
• Prevents eye strain
• Improves eye accommodation (adjustment of the lens that allows it to focus)
• Reduces blurred vision
• Reduces eye soreness
• Prevents eye dryness
• Prevents diplopia (double vision)

Dosage range: 4mg to 8mg per day²

CARDIOVASCULAR SUPPORT

Clinical Trial Results

• Improves blood lipid parameters in patients with mild hyperlipidemia
• Dose-dependently inhibits LDL cholesterol oxidation
• May contribute to the prevention of atherosclerosis
• Improves blood flow rate
• Decreases heart rate of athletes when doing endurance training

Dosage range: 4mg to 18mg per day³

BRAIN HEALTH

Clinical Trial Results

• Prevents age-related decline in cognitive function
• Improves psychomotor function in elderly subjects
• Improves marker for dementia in middle-aged and senior subjects and may contribute to the prevention of dementia from aging
• Improves cognitive function in healthy middle-aged and elderly subjects
• Decreases mental fatigue and confusion
• Improves erythrocyte antioxidant status to help transport oxygen to the brain

Dosage range: 6mg to 12mg per day⁴

SKIN HEALTH & BEAUTY-FROM-WITHIN

Clinical Trial Results

• Reduces fine lines and wrinkles
• Increases skin moisture levels
• Improves skin elasticity
• Prevents skin sagging
• Reduces visible signs of UV-aging within four to six weeks of use
• Prevents photo-aging of skin
• Prevents UV damage
• Improves skin conditions in all layers of the skin (corneocyte layer, epidermis, basal layer and dermis)

Dosage range: 4mg to 6mg per day⁵

ATHLETIC PERFORMANCE & ENERGY LEVELS

Clinical Trial Results

• Improves power output by 15%
  and reduces racing time by 5% in competitive cyclists
  • Promotes recovery from exercise
  • Prevents muscle fatigue
  • Improves endurance
  • Increases strength in healthy subjects
  • Increases grip strength in sufferers of tennis elbow by 93%
  • Decreases lactic acid levels
  • Decreases respiratory parameters during exercise
  • Helps prevent muscle damage and inflammation in elite soccer players
  • May be effective in preventing exercise induced free radical production
  • Improves oxidative status in athletes
  • Prevents joint and muscle soreness after exercise
  • Decreases heart rate in athletes doing endurance training
  • Dosage range 4mg to 12mg per day

IMMUNE SYSTEM MODULATION

Clinical Trial Results

• Improves a variety of immunity markers in subjects at only 2mg per day in eight weeks
  • Increases the total number of antibody-producing B-cells
  • Amplifies natural killer cell cytotoxic activity
  • Leads to increased number of T-cells
  • Stimulates white blood cell counts
  • Significantly increases delay-type hypersensitivity response
  • Dramatically reduces DNA damage
  • Raises immunoglobulin levels in healthy athletes
  • Suppresses lymphocyte activation in patients with allergic rhinitis and
  pollen-related asthma
  • Leads to therapeutic improvement in patients suffering from auto-immune disease
  • Dosage range 2mg to 4mg per day

FERTILITY & SPERM IMPROVEMENT

Clinical Trial Results

• Improves sperm functioning
  • Increases sperm linear velocity
  • Improves sperm quality
  • Increases sperm motility
  • Decreases reactive oxygen species in sperm
  • May be used to decrease male idiopathic infertility
  • Improves conception rate in infertile men
  • Also improves sperm functioning and motility in normal men without any fertility issues
  • Dosage 16mg per day

ANTI-AGING & CELLULAR HEALTH

Clinical Trial Results

• Skin Health and Beauty-from-Within
  • Eye & Brain Health
  • Joint, Tendon & Muscle Health
  • Cardiovascular Protection
  • Immune System Modulation
  • Strength, Endurance and Energy
  • Dosage range 4mg to 12mg per day

In-Vitro Research Results

• Mitochondria protection
  • Prevention of damage to DNA
  • Profound inhibition of oxidation
  • Safe & natural anti-inflammatory activity

MAJOR AREAS OF PRE-CLINICAL RESEARCH

• Support of Healthy Cell Lines 46 studies
  • Gastrointestinal Health 31 studies
  • Glucose Metabolism Management 25 studies
  • Liver & Kidney Health 23 studies
  • Respiratory Health 4 studies

WHAT IS ASTAZINE®?

AstaZine® is a line of natural astaxanthin products from Haematococcus pluvialis microalgae produced in a fully-closed, 100%-glass tube ecofriendly photobioreactor system.
AstaZine®:

• Contains 97% pure astaxanthin in the carotenoid fraction and just 3% of other carotenoids
  • The world’s first Organically Certified astaxanthin product (certified by Ecocert®)
  • Covered by two NDIs with US FDA at 12mg and 24mg per day
  • Supported with 239 health claims submitted to US FDA without objection
  • The only astaxanthin with two European Novel Foods approvals for both supercritical CO2 and ethanol extracts.
  • Self-affirmed GRAS
  • Registered for sale in most of the world’s most regulated markets

Algae Health Sciences, Inc., a subsidiary of BGG, focuses on the production and marketing of efficacious ingredients from natural algae sources. Algae Health Science’s flagship product, AstaZine® Natural Astaxanthin, is extracted from the world’s first Certified Organic Haematococcus pluvialis microalgae.

For more information, please contact us.

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DISPERSA™ : TURNING OILS INTO TRANSPARENT AND
STABLE WATER DISPERSIONS

Thanks to astaxanthin’s diverse array of clinically validated health benefits it has become known as “king of the carotenoids” and is becoming widely used in food and nutritional supplements.

However, two key challenges have limited its use in drink formulations:

• Poor solubility in water
• Intense pigment profile which leads to staining of the mouth & tongue and containers

BGG has taken an innovative approach to overcome these two challenges by formulating Astaxanthin using it’s a state-of-the-art Dispersa™ technological platform. ASTAXANTHIN Water Dispersible Emulsion Dispersa™ – Brochure

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Reference:

1. Nishida, Y., Yamashita, E., Miki, W. (2007). “Comparison of Astaxanthin’s Singlet Oxygen Quenching Activity with Common Fat and Water Soluble Antioxidants.” Carotenoid Science, Vol.11, 2007, 16-20.

2. • Lee, S., Bai, S., Lee, K., Namkoong, S., Na, H., Ha, K., Han, J., Yim, S., Chang, K., Kwon, Y., Lee, S., Kim, Y. (2003). “Astaxanthin Inhibits Nitric Oxide Production and Inflammatory Gene Expression by Suppressing IkB Kinase-dependent NFR-kB Activation.” Molecules and Cells. 16(1):97- 105.
   • Ohgami, K., Shiratori, K., Kotake, S., Nishida, T., Mizuki, N., Yazawa, K., Ohno, S. (2003). “Effects of Astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo.” Investigative Ophthalmology and Visual Science. 44(6):2694-701.
   • Choi, SK., Park, YS., Choi, DK., Chang, HI. (2008). “Effects of astaxanthin on the production of NO and the expression of COX-2 and iNOS in LPS-stimulated BV2 microglial cells.” Journal of Microbiology and Biotechnology. 18(12):1990-6.
   • Kishimoto, Y., Tani, M., Uto-Kondo, H., Iizuka, M., Saita, E., Sone, H., Kurata, H., Kondo, K. (2010). “Astaxanthin suppresses scavenger receptor expression and matrix metalloproteinase activity in macrophages.” European Journal of Nutrition. 49(2):119-26.

3. • Iwamoto, T., Hosoda, K., Hirano, R., Kurata, H., Matsumoto, A., Miki, W., Kamiyama, M., Itakura, H., Yamamoto, S., Kondo, K. (2000). “Inhibition of low-density lipoprotein oxidation by astaxanthin.” Journal of Atherosclerosis Thrombosis. 7(4):216-22.
   • Hiroshige, I. (2004). “Multivitamin and Carotenoid Supplements.” Progress in Medicinal Chemistry F0664B 0287-3648 Vol. 24;No.6;Page1437-1442.
   • Miyawaki, H., Takahashi, J., Tsukahara, H., Takehara, I. (2008). “Effects of astaxanthin on human blood rheology.” Journal of Clinical Biochemistry Nutrition. 43(2):9-74.
   • Talbott, S., Hantla, D., Capelli, B., Ding, L., Li, Y., Artaria, C. (2017). “Effect of Astaxanthin Supplementation on Cardiorespiratory Function in Runners.” EC Nutrition 11.6(2016:253-9.

4. • Satoh, A., Tsuji, S., Okada, Y., Murakami, N., Urami, M., Nakagawa, K., Ishikura, M., Katagiri, M., Koga, Y., Shirasawa, T. (2009). “Preliminary Clinical Evaluation of Toxicity and Efficacy of A New Astaxanthin-rich Haematococcus pluvialis Extract.” Journal of Clinical Biochemistry and Nutrition. 44(3):280-4.183
   • Katagiri, M., Satoh, A., Tsuji, S., Shirasawa, T. (2012). “Effects of astaxanthin-rich Haematococcus pluvialis extract on cognitive function: a randomized, double- blind, placebo-controlled study.” Journal of Clinical Biochemistry and Nutrition 2012 Sep;51(2):102-7.
   • Hongo et al. (2016). “Randomized controlled trial of the anti-fatigue effects of Astaxanthin on mental and physical loads simulating daily life.” Journal of Clinical Therapeutics & Medicines 32.7(2016):277-91.
   • Nakagawa, K., Kiko, T., Miyazawa, T., Carpentero Burdeos, G., Kimura, F., Satoh, A. (2011). “Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes.” The British Journal of Nutrition. 105(11):1563-71.

5. • Yamashita, E. (2002). “Cosmetic Benefit of Dietary Supplements Containing Astaxanthin and Tocotrienol on Human Skin.” Food Style. 21 6(6):112-17.
   • Tominaga, K., Hongo, N., Fujishita, M., Adachi, Y. (2017). “Protective effect of Astaxanthin on skin deterioration.” Journal of Clinical Biochemistry and Nutrition June 2017 10.3164/jcbn.17-35.
   • Savoure, N., Briand, G., Amory-Touz, M., Combre, A., Maudet, M. (1995). “Vitamin A status and metabolism of cutaneous polyamines in the hairless mouse after UV irradiation: action of beta-carotene and astaxanthin.” International Journal for Vitamin and Nutrition Research. 65(2):79-86.
   • Taisuke, S., Hirohiko, S., Hiromi, K., Kaoru, S., Yamashita, E. (2001). “Effects of Astaxanthin from Haematococcus pluvialis on human skin. Patch testing skin repeated application test effect on wrinkle reduction.” Flavor and Fragrance Journal Vol.29;No.12;Page.98-103(2001).